pone.0262616.s001.xlsx (10.65 kB)
Median codon coverages of anti-malarial drug resistance genes in the individual and pooled samples.
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posted on 2022-01-14, 18:25 authored by Swarnali Louha, Camelia Herman, Mansi Gupta, Dhruviben Patel, Julia Kelley, Je-Hoon M. OH, Janani Guru, Jean F. Lemoine, Michelle A. Chang, Udhayakumar Venkatachalam, Eric Rogier, Eldin Talundzic(XLSX)
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values (+/- 1time saving approachproviding allele frequencymedian codon coveragedried blood spotsdiv >< pcontinued chloroquine sensitivitycompared codon coverageμl blood showeddrug resistant markersplasmodium falciparum μl blood priorsequencing large numbersdeep sequencing yieldedlower parasite densityaf estimation may0 ct valuepooled sequencing approachdrug resistance genesseveral individual samplesμl priordrug resistancedeep sequencingsequencing successlarge numbergenes (<mdr1 dhps dhfr crt similar realrapid genotypingpooled samplesparasite dnaoften neededmolecular surveillancemixed infectionslow amountsindividual samplesgrouping samplescould leadconferring mutationsbased studiesassociated mutationsalternative costaf calls40 parasites
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