Table 1.xls (9.5 kB)
Mean (one standard deviation) plasma canrenone and 7-α-thiomethyl spironolactone (TMS) concentration following treatment with spironolactone at either 2 mg/kg/day or 4mg/kg/day for seven days at T1 (immediately prior to spironolactone dosing) and T2 (5 hours post-spironolactone dose) in 10 healthy purpose-bred Beagle dogs using a cross-over study design.
dataset
posted on 2024-02-23, 18:58 authored by Allison K. Masters, Jessica L. Ward, Emilie Guillot, Oliver Domenig, Lingnan Yuan, Jonathan P. MochelThe range of plasma canrenone and TMS at each timepoint following spironolactone treatment is also reported.
History
Usage metrics
Categories
Keywords
second treatment periodmineralocorticoid receptor antagonismbiochemical effects seenxlink "> treatmentkg po q24hrfollowing spironolactone treatmentdogs received 7day washout period09 ), angiotensinangiotensin ii (<xlink ">08 ),07 ),angiotensin peptidesweakly correlatedsurrogate markerstudy resultsstatistical differencesspironolactone followedspironolactone dosagessignificantly differsignificant increasessignificant increaserandomly allocatedplasma canrenonemass spectroscopymass spectrometryhealthy dogsday coursescomprehensive characterizationalternative armsadverse clinical
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC