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Maximal Percent Inhibition from Multiple Cycle (MC) and Single Cycle (SC) Assays

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posted on 2016-11-28, 04:30 authored by Zeyu Lin, Joseph Cantone, Hao Lu, Beata Nowicka-Sans, Tricia Protack, Tian Yuan, Hong Yang, Zheng Liu, Dieter Drexler, Alicia Regueiro-Ren, Nicholas A. Meanwell, Mark Cockett, Mark Krystal, Max Lataillade, Ira B. Dicker

Maximal Percent Inhibition from Multiple Cycle (MC) and Single Cycle (SC) Assays

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Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors
PLOS PathogensPLOS Pathogens

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polymorphic Gag variantsvivo MI efficaciesEC 50 valuesinhibitionVLPcleavageBVMpolymorphic Gag virusesGag Polymorphic VirusesMI-specific Gag affinitiesMPIradiolabel binding assayCASPgeneration MI bevirimatLCspacer peptide 1Gag polymorphic virusesAntiviral assay datacapsid p 24 capsidBMS -955176Maturation Inhibitors HIV

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