pntd.0010046.s005.xlsx (45.34 kB)
List of SNVs detected in the coding regions of L. tarentolae A150.1.
dataset
posted on 2021-12-16, 18:57 authored by Gaétan Roy, Arijit Bhattacharya, Philippe Leprohon, Marc Ouellette(XLSX)
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revealing biochemical pathwaysprominent defect observedgenetic knockout leddiv >< pcontaining gmp synthasechromosome 22 correspondedpotential drug targetsacivicin thus leadingacivicin binds covalentlyshown good activityreduced glutamate transportdecreased glutamate transportmain glutamate transporterleishmania tarentolae decreased transporttarentolae leishmania reduced uptakedrug resistancel acivicin susceptibilityacivicin resistantacivicin resistanceresistant strainresistant mutantprotozoan parasitesmodest roleepisomal expressioneither deletedcompetition experimentsamidotransferase domain
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