Ketamine evoked disruption of entorhinal and hippocampal spatial maps

 Companion code located at https://github.com/GiocomoLab/Masuda_et_al_2023

MEC_Neuropixels.zip

MEC spike times and behavior from acute Neuropixels insertions during a 1D VR linear track task

File names: [animal name]_[date]_baseline1_controlinjx1_ketamine1fr_corr.mat

• lickt = lick timestamps, of IR beam breaks
• lickx = position of animal at lick times
• post = timestamps of 50 Hz VR frames
• posx = position of animal at each VR frame
• speed = speed of animal at each VR frame
• trial = trial at each VR frame
• spike_depth: depth along electrode of peak channel of each cell
• all_cellCorrScore = correlation score between a trial and the baseline spatial template
• all_cellStabilityScore = spatial stability for each cell on each trial
• all_corrmatrix = firing correlation of each cell between each pair of trials
• all_drugEffectScores = [ketamine FR diff, control FR diff, ketamine FR effect score, ketamine corr effect score, spike depth] for each cell
•        FR effect score = the ratio ketamine vs control of the differences between the avg FR of the pre-injection trials and the the avg FR of the equivalent number of trials post-injection
• corr effect score = difference between the average of the corrScore in the 25 trials before ketamine and the average of the corrScore in the 25 trials after ketamine appication
• all_fr = mean firing rate per cell per trial per spatial bin
• all_fr_smoothed = save as all_fr, smoothed with Gaussian kernel
• all_frTime = firing rate of each cell averaged over each VR frame
• all_peakiness = mean crest factor of each cell
• all_spatialinfo = mean spatial information of each cell
• all_spatialInfoCurve = spatial information of each cell on each trial
• all_spike_idx = spike times for each cell, in VR bins
• all_waveforms = waveforms of each cell
• avg_all_cellCorrScore = avarge cellCorrScores curves for each trial
• avg_all_corrmatrix = trial by trial correlation for all cells
• avg_all_fr: mean firing rate per position bin per trial over all cells
• avg_cell_fr: mean firing rate over full session per cell

CA1_miniscope.zip

CA1 calcium transients from 1-photon imaging during a freely moving context exploration

Folder names: M[mouse number][F for female, nothing for male]

• behavIndividualsf.mat
• neuronIndivisualsf.mat
• sessions.mat
• thresh.mat