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Cardio_final.rds (1.92 GB)
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19
dataset
posted on 2020-12-21, 09:19 authored by Saskia Trump, Soeren LukassenSoeren Lukassen, Markus S. Anker, Robert Lorenz Chua, Johannes Liebig, Loreen Thürmann, Victor Max Corman, Marco Binder, Jennifer Loske, Christina Klasa, Teresa G. Krieger, Bianca P Hennig, Marey Messingschlager, Fabian Pott, Julia Kazmierski, Sven O. Twardziok, Jan Philipp Albrecht, Jürgen Eils, Sara Hadzibegovic, Alessia Lena, Bettina Heidecker, Thore Bürgel, Jakob Steinfeldt, Christine Goffinet, Florian Kurth, Martin Witzenrath, Maria Theresa Völker, Sarah Dorothea Müller, Uwe Gerd Liebert, Naveed Ishaque, Lars Kaderali, Leif-Erik Sander, Christian Drosten, Sven Laudi, Roland EilsRoland Eils, Christian ConradChristian Conrad, Ulf Landmesser, Irina LehmannThis dataset comprises single-cell RNA-Seq data of nasopharyngeal samples of 32 COVID-19
patients and 16 healthy controls, for a total of 48 samples. 25 COVID-19 patients and 10 controls were diagnosed with hypertension and treated with either ACE inhibitors (ACEi) or angiotensin receptor blockers(ARB) (SARS-CoV-2-positive: 10 ACEi and 15 ARB; SARS-CoV-2-negative: 6 ACEi and 4 ARB).
An
in-depth description is presented in the manuscript "Delayed viral clearance and exacerbated airway hyperinflammation in hypertensive COVID-19 patients"
(https://www.medrxiv.org/content/10.1101/2020.09.22.20199471v1).History
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COVID-19SARS-CoV-2respiratory tractsingle-cell sequencinggene expressiontranscriptomicsnasopharynxinflammationhypertensionRenin-angiotensin inhibitionangiotensin receptor antagonistsACE inhibitionCardiology (incl. Cardiovascular Diseases)Medical VirologyRespiratory DiseasesBioinformaticsGene Expression (incl. Microarray and other genome-wide approaches)Virology
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