pone.0258977.s001.xlsx (15.42 kB)
Gene symbols, names, and cochlear expressions of the 84 immune-related genes examined by real-time RT-PCR array in this study.
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posted on 2021-10-22, 17:25 authored by Kensuke Uraguchi, Yukihide Maeda, Junko Takahara, Ryotaro Omichi, Shohei Fujimoto, Shin Kariya, Kazunori Nishizaki, Mizuo AndoThe expressions of inflammatory and immune-related genes in the cochleae of 12-month-old relative to 6–7-week-old mice are tabulated. The expressions of 84 immune-related genes were analyzed by real-time RT-PCR array. As a result, 33 upregulated and 7 downregulated genes were detected with greater than a twofold or less than a 0.5-fold change, respectively, with a P-value <0.05 for significantly different expression levels between the 12-month-old and 6–7-week-old mice (n = 3, t-test).
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related hearing lossmajor proinflammatory moleculesgenomic regulatory regionsepidemiological data suggestbioinformatic analyses predictedrelated genes revealedrelated genes (<young control micelike receptor signalingκb would interactold mice indicatedinteracting inflammatory moleculesdiv >< pspiral ligament ),differentially regulated genesaged cochlear tissueseight upregulated degsdifferentially regulatedspiral ligamentaged mice40 genesold cochleaemice cochleaetnf signalingspiral limbuscochlear structurescochlear sectionschemokine signalingaged cochleaeκb subunittwofold changetnf tlr9 time rtstria vascularisseven immuneremarkable upregulationspositive macrophagesnuclear factornfkb1 mouse studylateral wallkappa bimmunolocalized ubiquitouslyimmunohistochemistry analysisimmune reactionsil1b il18rap il18r1 ifit1 histological sectionsfunctional pathwaysclec4e casp1 card9 aging cochleaeadvanced stage>) occurred6 months6 %)3 %)
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