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Extended_data_IGF1_cancer.xlsx (982.64 kB)

Elucidating the genetic architecture underlying IGF1 levels and its impact on genomic instability and cancer risk

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Version 2 2020-11-23, 10:19
Version 1 2020-11-18, 21:11
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posted on 2020-11-23, 10:19 authored by Stasa StankovicStasa Stankovic, Felix R. Day, Yajie Zhao, Claudia Langenberg, Nicholas J. Wareham, 23andMe Research Team, John R.B. Perry, Ken K. Ong
Extended data for the article "Elucidating the genetic architecture underlying IGF1 levels and its impact on genomic instability and cancer risk". The tables in the Extended data will give more information on the discovery of genome-wide significant independent signals associated with levels of IGF1, replication study, pathway analysis, as well as the results for Mendelian Randomization analysis on IGF1 and its causal inference on mosaic loss of chromosome Y in leucocytes and cancer.

Funding

Aetiology of type 2 diabetes and related metabolic disorders

Medical Research Council

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Child Growth and development

Medical Research Council

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Institutional Strategic Support Fund

Wellcome Trust

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