ja3083494_si_003.cif (16.75 kB)
Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2‑Alkylazaarenes to N‑Boc Imines and Nitroalkenes
dataset
posted on 2012-11-07, 00:00 authored by Daniel Best, Szymon Kujawa, Hon Wai LamA chiral Pd(II)–bis(oxazoline) complex was found
to be highly
effective in promoting the first direct diastereo- and enantioselective
addition of alkylazaarenes to N-Boc aldimines
and nitroalkenes under mild conditions. Deprotection of Boc-protected
products proceeded readily to provide amines in high yields.