Development of the Intramolecular Prins Cyclization/Schmidt Reaction for the Construction of the Azaspiro[4,4]nonane: Application to the Formal Synthesis of (±)-Stemonamine

dataset

posted on 2011-02-18, 00:00 authored by Zhi-Hua Chen, Yong-Qiang Tu, Shu-Yu Zhang, Fu-Min Zhang

A TiCl₄-promoted tandem intramolecular Prins cyclization/Schmidt reaction has been designed and developed to be an efficient method for the construction of the azaspiro[4,4]nonane. The present tandem protocol has been employed to construct the tricyclic azaquaternary skeleton (ring A, B, and C) of stemonamine.

History

Usage metrics

Keywords

azaspiro StemonamineA Cyclization tandem protocol Application intramolecular Prins tricyclic azaquaternary skeleton Formal Synthesis cyclization stemonamine Construction TiCl Azaspiro method construction Intramolecular

Licence

CC BY-NC 4.0

Development of the Intramolecular Prins Cyclization/Schmidt Reaction for the Construction of the Azaspiro[4,4]nonane: Application to the Formal Synthesis of (±)-Stemonamine

History

Usage metrics

Categories

Keywords

Licence

Exports