(A) B cells from healthy donors were co-stimulated with CpG ODN 2006 inactivated A/Vic11 viruses and interleukin 15. Strain-specific and HA stalk-reactive IgG in supernatants of activated B cells were detected after 6 days. (B) Fold change in cross-reactive antibodies. (B) Correlation between influenza specific antibodies and HA antigenic sequence. No correlation between cross-reactive antibodies and HA sequence was detected.
Funding
Zunyi Medical University (JH) Visiting Scholar Grant 201408525075, National Institutes of Health - National Institute of Allergy, Immunology, and Infectious Disease Grants AI098112, AI069351, AI109946