Data_Sheet_1_TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility.docx (681.73 kB)

Data_Sheet_1_TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility.docx

dataset

posted on 2022-11-30, 04:35 authored by Takeshi Sekiya, Yukino Ogura, Hirayasu Kai, Atsushi Kawaguchi, Shino Okawa, Mikako Hirohama, Takahiro Kuroki, Wataru Morii, Akira Hara, Yuji Hiramatsu, Shigemi Hitomi, Yasushi Kawakami, Yoshihiro Arakawa, Kazushi Maruo, Shigeru Chiba, Hiromichi Suzuki, Hiroshi Kojima, Hirokazu Tachikawa, Kunihiro Yamagata

COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity. Here, we found that rs12329760 in the TMPRSS2 gene, a missense variant common in East Asian populations, contributes to protection against SARS-CoV-2 infection. TMPRSS2 is a protease responsible for SARS-CoV-2 entry and syncytium formation. rs12329760 (c.478G>A, p. V160M) was associated with a reduced risk of moderate symptoms. The enzymatic activity of Met¹⁶⁰-TMPRSS2 was lower than that of Val¹⁶⁰-TMPRSS2, and thus the viral entry and the syncytium formation of SARS-CoV-2 were impaired. Collectively, these results indicate that the genetic variation in TMPRSS2, which is common in East Asians, is one of the molecular determinants of COVID-19 susceptibility.