Data_Sheet_1_1_Advanced fructo-oligosaccharides improve itching and aberrant epidermal lipid composition in children with atopic dermatitis.xlsx (41.97 kB)

Data_Sheet_1_1_Advanced fructo-oligosaccharides improve itching and aberrant epidermal lipid composition in children with atopic dermatitis.xlsx

dataset

posted on 2024-04-29, 04:14 authored by Sukyung Kim, Bae-Gon Kang, Soonok Sa, Se Young Park, Kyungheon Ryu, Jinyoung Lee, Boram Park, Mijeong Kwon, Yeonghee Kim, Jiwon Kim, Sanghee Shin, Sehun Jang, Byung Eui Kim, Jaewoong Bae, Kangmo Ahn, Kwang-Hyeon Liu, Jihyun Kim

Introduction

The effects of fructo-oligosaccharides (FOS) on atopic dermatitis (AD) have not been determined.

Methods

In a randomized, double-blind, placebo-controlled trial, children with AD aged 24 months to 17 years received either advanced FOS containing 4.25 g of 1-kestose or a placebo (maltose) for 12 weeks.

Results

The SCORAD and itching scores were reduced in patients treated with both FOS (all p < 0.01) and maltose (p < 0.05 and p < 0.01). Sleep disturbance was improved only in the FOS group (p < 0.01). The FOS group revealed a decreased proportion of linoleic acid (18:2) esterified omega-hydroxy-ceramides (EOS-CERs) with amide-linked shorter chain fatty acids (C28 and C30, all p < 0.05), along with an increased proportion of EOS-CERs with longer chain fatty acids (C32, p < 0.01).

Discussion

FOS may be beneficial in alleviating itching and sleep disturbance, as well as improving skin barrier function in children with AD.