CovMulNet19.zip (1.03 MB)

CovMulNet19.zip

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posted on 15.09.2020 by nina verstraete, Giulia Bertagnolli, Arsham Ghavasieh, Vera Pancaldi, Giuseppe Jurman, Manlio De domenico
CovMulNet19 is a comprehensive network containing all available known interactions involving SARS-CoV-2 proteins, interacting-human proteins, diseases and symptoms that are related to these human proteins, and compounds that can potentially target them. Extensive network analysis methods, based on a bootstrap approach, allow us to prioritise a list of diseases that display a high similarity to \covid and a list of drugs that could potentially be beneficial to treat patients. As a key feature of CovMulNet19, the inclusion of symptoms allows a deeper characterization of the disease pathology, representing a useful proxy for CoVid19-related molecular processes. We recapitulate many of the known symptoms of the disease and we find the most similar diseases to COVID-19 reflect conditions that are risk factors in patients.

Funding

INSERM

National Health and Medical Research Council

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Foundation Toulouse Cancer Santé

BioInfo4Women programme at the BarcelonaSupercomputing Cente

PierreFabre Research Institute as part of the Chair of Bioinformatics in Oncologyof the CRCT

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