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Conditional associations for BRCA1 and BRCA2 top SNPs.

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posted on 27.07.2016, 13:12 authored by Elena Vigorito, Karoline B. Kuchenbaecker, Jonathan Beesley, Julian Adlard, Bjarni A. Agnarsson, Irene L. Andrulis, Banu K. Arun, Laure Barjhoux, Muriel Belotti, Javier Benitez, Andreas Berger, Anders Bojesen, Bernardo Bonanni, Carole Brewer, Trinidad Caldes, Maria A. Caligo, Ian Campbell, Salina B. Chan, Kathleen B. M. Claes, David E. Cohn, Jackie Cook, Mary B. Daly, Francesca Damiola, Rosemarie Davidson, Antoine de Pauw, Capucine Delnatte, Orland Diez, Susan M. Domchek, Martine Dumont, Katarzyna Durda, Bernd Dworniczak, Douglas F. Easton, Diana Eccles, Christina Edwinsdotter Ardnor, Ros Eeles, Bent Ejlertsen, Steve Ellis, D. Gareth Evans, Lidia Feliubadalo, Florentia Fostira, William D. Foulkes, Eitan Friedman, Debra Frost, Pragna Gaddam, Patricia A. Ganz, Judy Garber, Vanesa Garcia-Barberan, Marion Gauthier-Villars, Andrea Gehrig, Anne-Marie Gerdes, Sophie Giraud, Andrew K. Godwin, David E. Goldgar, Christopher R. Hake, Thomas V. O. Hansen, Sue Healey, Shirley Hodgson, Frans B. L. Hogervorst, Claude Houdayer, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Lauren Jacobs, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska-Bieniek, Uffe Birk Jensen, Esther M. John, Joseph Vijai, Beth Y. Karlan, Karin Kast, KConFab Investigators, Sofia Khan, Ava Kwong, Yael Laitman, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Jan Lubinski, Phuong L. Mai, Siranoush Manoukian, Sylvie Mazoyer, Alfons Meindl, Arjen R. Mensenkamp, Marco Montagna, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Dieter Niederacher, Edith Olah, Olufunmilayo I. Olopade, Kai-ren Ong, Ana Osorio, Sue Kyung Park, Ylva Paulsson-Karlsson, Inge Sokilde Pedersen, Bernard Peissel, Paolo Peterlongo, Georg Pfeiler, Catherine M. Phelan, Marion Piedmonte, Bruce Poppe, Miquel Angel Pujana, Paolo Radice, Gad Rennert, Gustavo C. Rodriguez, Matti A. Rookus, Eric A. Ross, Rita Katharina Schmutzler, Jacques Simard, Christian F. Singer, Thomas P. Slavin, Penny Soucy, Melissa Southey, Doris Steinemann, Dominique Stoppa-Lyonnet, Grzegorz Sukiennicki, Christian Sutter, Csilla I. Szabo, Muy-Kheng Tea, Manuel R. Teixeira, Soo-Hwang Teo, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Elizabeth J. van Rensburg, Liliana Varesco, Raymonda Varon-Mateeva, Athanassios Vratimos, Jeffrey N. Weitzel, Lesley McGuffog, Judy Kirk, Amanda Ewart Toland, Ute Hamann, Noralane Lindor, Susan J. Ramus, Mark H. Greene, Fergus J. Couch, Kenneth Offit, Paul D. P. Pharoah, Georgia Chenevix-Trench, Antonis C. Antoniou

The table shows the HR estimate. 95% CI and p-value for the conditional analysis adjusting for the lead SNP in the univariate analysis for BRCA1 (left hand side) or BRCA2 mutation carriers (right had side). SNPs correspond to: rs10124837, the strongest associated in BRCA1; rs62543583, the strongest associated in BRCA2 mutation carriers; rs7046326, the strongest associated in BRCA1/2 meta-analysis; rs3814113, was the strongest associated variant in the initial GWAS analysis. “HR”, hazard ratio; “CI”, confidence interval.

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