ppat.1010162.s007.xlsx (12.62 kB)
Clinical, blood and necropsy observations in pigtail macaques (PTM) challenged with SARS-CoV-2 (n = 4).
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posted on 2021-12-20, 18:43 authored by Alexandra Melton, Lara A. Doyle-Meyers, Robert V. Blair, Cecily Midkiff, Hunter J. Melton, Kasi Russell-Lodrigue, Pyone P. Aye, Faith Schiro, Marissa Fahlberg, Dawn Szeltner, Skye Spencer, Brandon J. Beddingfield, Kelly Goff, Nadia Golden, Toni Penney, Breanna Picou, Krystle Hensley, Kristin E. Chandler, Jessica A. Plante, Kenneth S. Plante, Scott C. Weaver, Chad J. Roy, James A. Hoxie, Hongmei Gao, David C. Montefiori, Joseph L. Mankowski, Rudolf P. Bohm, Jay Rappaport, Nicholas J. ManessValues in parenthesis represent days post SARS-CoV-2 infection. Neutrophilia, eosinophilia, basophilia, monocytosis defined as ≥ 2-fold increase over baseline1. Lymphocytopenia, monocytopenia, eosinopenia, basopenia defined as a 35% reduction from baseline1. CRP: C-reactive protein.
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severe cardiovascular symptomsmacaca nemestrina highly transmissible variantsexpress cytotoxic moleculesdiv >< palso noted increasesthus may servesiv ), includingpulmonary pathologic lesionspredominantly cd4 +.pigtail macaque (<respiratory viral challengeuseful animal modelsimian immunodeficiency virussevere disease coursenovel coronavirus sarsreveals new immunereveals newincluding cd4thus proposedpulmonary infiltratespigtail macaquesimmune dynamicsanimal models>) modelviral dynamicsupregulate cd8understanding mechanismstesting vaccinesstudying pathogenesisneutralizing antibodiesinfections risingextensively studieddecember 2021data demonstratecomplex signaturescoagulation markerscausative agentassessing sars>) demonstrate2 viral
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