Table 2.xls (13.5 kB)
Class, mode of action, IC50 and MIC50 values of the 20 most potent compounds in the Pandemic Response Box against Madurella mycetomatis.
dataset
posted on 2022-02-04, 18:36 authored by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de SandeCompounds with MIC50 value indicated with an asterisk (*) were determined in previous works [19–21]. Their efficacy to M. mycetomatis is again demonstrated here with their low IC50 values.
History
Usage metrics
Categories
Keywords
pandemic response boxminimal inhibitory concentrationsmedicinal chemistry optimisationfungal orders sordarialesaminoquinolone derivative tafenoquinemadurella tropicana madurella pseudomycetomatis galleria mellonella find novel drugsfalciformispora senegalensis div >< pseven inhibited growthpromising drug candidatesmadurella mycetomatis benzimidazole carbamates fenbendazoleeumycetoma promising candidatesmycetomatis vivo vitro novel antifungalstreat eumycetomasignificantly prolongmycetos ).medicopsis romeroilike moleculeslarvae survivalfour compoundsfive speciescure ratescompounds activealso serve26 compounds
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC