posted on 2019-03-22, 00:00authored byKristers Ozols, Yun-Suk Jang, Nicolai Cramer
The
synthesis of a set of cobalt(III)-complexes equipped with trisubstituted
chiral cyclopentadienyl ligands is reported, and their steric and
electronic parameters are mapped. The application potential of these
complexes for asymmetric C–H functionalizations with 3d-metals
is shown by the synthesis of dihydroisoquinolones from N-chlorobenzamides with a broad range of alkenes. The transformation
proceeds with excellent enantioselectivities of up to 99.5:0.5 er and high regioselectivities. The observed values outperform
the best rhodium(III)-based methods for this reaction type. Moreover,
challenging substrates such as alkyl alkenes also react with high
regio- and enantioselectivities.