pgen.1011104.s005.xlsx (12.83 kB)
Annotation enrichment weights estimated by PAINTOR+ in locus simulations.
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posted on 2023-12-28, 18:29 authored by Wenmin Zhang, Hamed Najafabadi, Yue LiAnnotation enrichment weights estimated by PAINTOR+ in locus simulations.
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widespread linkage disequilibriumunderlying genetic architecturesummarizing posterior probabilitiesreduced computation timepropose effective strategieslevel causal configurationshigh computational costmultiple causal variantsidentifying causal variantsfive functional biomarkersclinically relevant phenotypesthus improve fineintegrating summary statisticsincorporate functional annotationsgenome may helpdiv >< pwide association studiesmapping methods conductingfunctional annotationsprioritize variantsfunctional followbiologically relevantart methodswide utilityuk biobanksparse projectionpossible existenceinformed priorsgenomic locusexhaustive searchestimating hyperparametersefficient finederive functionallyclassical finechallenging duebuild connections
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