Anatomy of the left ventricle in fibrotic non-ischaemic dilated cardiomyopathy (NIDCM)

Supporting data for the study titled "Left Ventricular Shape Predicts Arrhythmic Risk in Fibrotic Dilated Cardiomyopathy" published in Europace (https://doi.org/10.1093/europace/euab306)

Collection of 156 computational meshes of the anatomy of the left ventricle of 156 subjects with fibrotic NIDCM

Data acquisition and segmentation

Original Late Gadolinium Enganced (LGE-CMR) images originate from a cohort of 157 patients enrolled in the Royal Brompton Hospital Cardiovascular Biobank Project.

Short axis LGE-CMR images stacks were acquired with an acquired scanning resolution of 1.3-2.2mm in plane and with a 7-10.5mm slice thickness.

LGE-CMR stacks were manually segmented. An additional point was marked, the most basal point of the RV epicardium that meets the liver, required to break the circumferential symmetry of the LV in the ventricular shape models, and providing a marker for the most basal slice (images above this slice were removed).

3D meshing

The LV end diastolic anatomy was reconstructed from the short axis image contours using high order interpolation meshes. An idealised ellipsoid (with 96 elements, 194 nodes and 4656 degrees of freedom) was tailored to the dimensions of each case, and image registration and mesh warping techniques used to fit an idealised ellipsoid to each patient’s contours. High-order interpolation basis functions (cubic Hermite) in the meshes were used to interpolate the typically sparse out of plane resolutions in the short axis acquisitions.

The 156 meshes were then spatially aligned by their centres of mass, and oriented by their basal planes and manually marked points at the RV epicardium.