posted on 2021-07-16, 22:14authored byHao-Fei Yu, Cai-Feng Ding, Lan-Chun Zhang, Xin Wei, Gui-Guang Cheng, Ya-Ping Liu, Rong-Ping Zhang, Xiao-Dong Luo
Alstoscholarisine
K, an indole alkaloid with eight chiral carbons
and featuring a novel 6/5/6/6/6/6/6/5 octacyclic architecture, was
found to be specific to the gall-infected leaves of Alstonia
scholaris. Its structure was elucidated by spectroscopy,
computational analysis, and single-crystal X-ray diffraction. The
unusual highly fused cage-like pyrrolo[1,2-a]pyrimidine
structure with an additional −C4N unit is possibly
derived from a combination of monoterpenoid indole and polyamine pathways.
The fascinating compound exhibited significant antibacterial bioactivities
by targeting cell membranes.