13071_2021_4947_MOESM1_ESM.xlsx (413.77 kB)

Additional file 1 of Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

dataset

posted on 2021-08-29, 03:15 authored by Chloé Rosa-Teijeiro, Victoria Wagner, Audrey Corbeil, Ilda d’Annessa, Philippe Leprohon, Rubens L. do Monte-Neto, Christopher Fernandez-Prada

Additional file 1: Dataset S1. Log2-transformed 16 × TPT-resistant mutants/WT reads ratios for non-overlapping 5 kb genomic windows for the 36 L. infantum chromosomes in the three TPT-resistant strains.

Funding

Fonds de Recherche du Québec - Nature et Technologies Natural Sciences and Engineering Research Council of Canada Canada Foundation for Innovation Conselho Nacional de Desenvolvimento Científico e Tecnológico

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Keywords

Protozoan parasites Leishmania DNA topoisomerases Topotecan Drug resistance SNPs

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