Version 2 2024-06-05, 04:17Version 2 2024-06-05, 04:17
Version 1 2019-11-21, 15:27Version 1 2019-11-21, 15:27
chapter
posted on 2024-06-05, 04:17authored byU Dhagat, TL Nero, WL Kan, TR Hercus, SE Broughton, NA de Weerd, BJ Jenkins, A Mansell, Mark GuthridgeMark Guthridge, PJ Hertzog, AF Lopez, MW Parker
Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation, and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons, and colony-stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.