Hositisines A and B, new alkaloids from the stems of Ormosia hosiei Hemsl. et Wils

Ni, Lin; Chen, Jingxin; Zhang, Xiaoqin; Wu, Meiting; Zhang, Linjing; Wu, Zujian; Huang, Mingqing; Xu, Huiyou

doi:10.6084/m9.figshare.9850841.v1

gnpl_a_1666387_sm8847.pdf (1.94 MB)

Hositisines A and B, new alkaloids from the stems of Ormosia hosiei Hemsl. et Wils

journal contribution

posted on 2019-09-16, 12:22 authored by Lin Ni, Jingxin Chen, Xiaoqin Zhang, Meiting Wu, Linjing Zhang, Zujian Wu, Mingqing Huang, Huiyou Xu

Two new alkaloids, named hositisines A (1) and B (2), with two known alkaloids (3 and 4) were isolated from the stems of Ormosia hosiei Hemsl. et Wils. Their structures were confirmed by UV, HRESIMS, NMR spectra. The absolute configurations of 1 and 2 were determined by quantum ECD calculation and ECD, respectively. Compounds 1–3 could significantly reduce the LDH release at the concentration 50 μM, which showed they could strongly protect the PC12 cells exposed to oxygen and glucose deprivation/reoxygenation (OGD/R) injury.