gnpl_a_1160235_sm0978.pdf (296.74 kB)
Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats
journal contribution
posted on 2016-03-21, 17:02 authored by M. Cristani, A. Speciale, F. Mancari, T. Arcoraci, D. Ferrari, D. Fratantonio, A. Saija, F. Cimino, D. TrombettaAcetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract.