gnpl_a_986659_sm4503.docx (309 kB)
Antigiardial activity of glycoproteins and glycopeptides from Ziziphus honey
Version 2 2015-10-08, 16:04
Version 1 2015-10-08, 16:04
journal contribution
posted on 2015-10-08, 16:04 authored by Seif Eldin A. Mohammed, Ahmed S. Kabashi, Waleed S. Koko, M. Kamran AzimNatural honey contains an array of glycoproteins, proteoglycans and glycopeptides. Size-exclusion chromatography fractionated Ziziphus honey proteins into five peaks with molecular masses in the range from 10 to >200 kDa. The fractionated proteins exhibited in vitro activities against Giardia lamblia with IC50 values ≤ 25 μg/mL. Results indicated that honey proteins were more active as antiprotozoal agents than metronidazole. This study indicated the potential of honey proteins and peptides as novel antigiardial agents.