posted on 2023-08-28, 19:40authored byZi-Ling Tan, Yu-Chan Chen, Jian-Peng Zhang, Hong-Xin Liu, Wei-Min Zhang, Han-Jing Yan
Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of Phomopsis lithocarpus FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid (1) as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds 3 and 9 displayed potent cytotoxicity against HepG-2 cell line, and compounds 2, 3 and 12 showed significant anti-inflammatory activities.
Funding
This work was financially supported by Guangdong Special Support Program (2019TQ05Y375), Guangdong Provincial Special Fund for Marine Economic Development Project ([2021]054), and Guangdong Provincial Project for Science and Technology (No. 2021A1515011549).