myc heterozygotes have a reduced mutation frequency and increased lifespan.

(A) Western analyses showing levels of Myc and the loading control γ-tubulin from 20 female adult heads of the genotypes +/+; lacZ #2/+ (labeled as +), myc4/+; lacZ #2/+ (labeled as myc/+) and myc4/+; lacZ #2/+; myc:GFP/+ (labeled as myc/+, myc:GFP). Adults were 1–4 days old. (B) lacZ mutation frequency of +/+; lacZ #2/+ (labeled as +) and myc4/+; lacZ #2/+ (labeled as myc4/+) and myc4/+; lacZ #2/+; myc:GFP/+ (labeled myc4/+; myc:GFP/+). *indicates p<0.05 (student’s t-test). (C) Lifespan analyses of +/+; lacZ #2/+ (labeled as +), myc4/+; lacZ #2/+ (labeled as myc4/+) and myc4/+; lacZ #2/+; myc:GFP/+ (labeled as myc4/+, myc:GFP). The lifespan of myc4/+; lacZ #2/+ heterozygotes is significantly different to +/+; lacZ #2/+ and myc4/+; lacZ #2/+; myc:GFP/+ (which are indistinguishable) p = 0.002 (Log-rank test).

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