Figure_4.tif (351.35 kB)
βlow-cells have an altered cAMP signaling.
figure
posted on 2009-05-18, 02:18 authored by Melis Karaca, Julien Castel, Cécile Tourrel-Cuzin, Manuel Brun, Anne Géant, Mathilde Dubois, Sandra Catesson, Marianne Rodriguez, Serge Luquet, Pierre Cattan, Brian Lockhart, Jochen Lang, Alain Ktorza, Christophe Magnan, Catherine KargarEffects of 5.5 mM and 16.7 mM glucose±10 nM GLP-1 on insulin release (A) and cAMP content (B) in βhigh and βlow-cells assessed by static incubation experiments (n = 3–5). (C) Effects of 5.5 mM and 16.7 mM glucose±5 mM db-cAMP on insulin secretion in βhigh and βlow-cells (n = 3–5). n represents the number of independent cell preparations from 6 pooled rats each. Data are means±SEM. *, p<0.05 and **, p<0.01.
