N-Benzylhydroxylamine Addition to
β-Aryl Enoates. Enantioselective
Synthesis of β-Aryl-β-amino Acid
Precursors

Sibi, Mukund P.; Liu, Mei

doi:10.1021/ol006500e.s001

ol006500e_si_001.pdf (121.55 kB)

N-Benzylhydroxylamine Addition to β-Aryl Enoates. Enantioselective Synthesis of β-Aryl-β-amino Acid Precursors

journal contribution

posted on 2000-09-29, 00:00 authored by Mukund P. Sibi, Mei Liu

Chiral Lewis acid catalyzed N-benzylhydroxylamine addition to pyrrolidinone-derived enoates afforded β-aryl-β-amino acid derivatives in high enantiomeric purity with moderate to very good chemical efficiency.

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Keywords

benzylhydroxylamine addition enantiomeric purity Precursors Chiral Lewis acid chemical efficiency Benzylhydroxylamine Addition Enoate Aryl derivative enoate aryl Enantioselective Synthesis

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