<i>i</i>NKT cell subtypes in the periphery.

<p>(A–C) FACS profile of peripheral <i>i</i>NKT cells in B6 mice. α-GalCer/CD1d dimer<sup>+</sup> TCRβ<sup>+</sup><i>i</i>NKT cells (A) and <i>i</i>NKT subtypes based on the expression of CD44 and NK1.1 (B) or CD4 and IL-17RB (C) in spleen, liver, BM, lung, inguinal LN, and mesenteric LN from B6 or <i>Il17rb</i><sup>−/−</sup> mice. Numbers indicate percentage of total mononuclear cells (A) and <i>i</i>NKT cells (B, C). (D) Number of cells of each <i>i</i>NKT subtype based on the expression of IL-17RB and CD4 in thymus and periphery of B6 and BALB/c mice. Cell numbers were calculated based on the results from <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001255#pbio-1001255-g004" target="_blank">Figures 4A, 4C</a>, <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001255#pbio.1001255.s008" target="_blank">S8A</a>, and S8B. IL-17RB<sup>+</sup><i>i</i>NKT cells were mainly localized in spleen, lung, inguinal LN, and mesenteric LN, whereas hardly any were observed in liver and BM. One representative experiment of three is shown.</p>