<i>In vitro</i> cytotoxicity of some <i>Narcissus</i> plants extracts

<div><p>This study compares the chloroform extracts of bulbs and roots of <i>Narcissus papyraceus</i> Ker Gawl. and <i>Narcissus tazetta</i> L. The cytotoxicity of the plant extracts was evaluated against human hepatocellular carcinoma cell line (HEPG2) and colon carcinoma cell line (HCT116) in comparison to doxorubicin. The extracts from the after-flowering (AF) bulbs of <i>N. tazetta</i> L. and <i>N. papyraceus</i> exhibited strong cytotoxic activity against HEPG2 (IC<sub>50</sub>: 2.2, 3.5 μg mL<sup>− 1</sup>) and HCT116 (IC<sub>50</sub>: 4.2, 3.9 μg mL<sup>− 1</sup>) cell lines, respectively. <i>N. tazetta</i> L. bulbs exhibited the least cell viability percentage in HepG-2 cell line (5.32%), while the AF root extracts of <i>N. papyraceus</i> exhibited the least cell viability percentage in HCT116 cell line (4.93%), when applied at a concentration of 50 μg mL<sup>− 1</sup>, thereby being more active than doxorubicin at the same concentration.</p></div>