<i>Daphne striata</i> Tratt. and <i>D. mezereum</i> L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties

<p>In this study, we investigated for the first time the anti-proliferative and antioxidant properties of <i>D. mezereum</i> and <i>D. striata</i>. The aerial parts were extracted by maceration with <i>n</i>-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. <i>D. mezereum</i> dichloromethane extract showed a remarkable anti-proliferative with an IC<sub>50</sub> of 6.08 μg/mL against LNCaP cells. Experimental data indicate that <i>Daphne</i> species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs.</p>