<i>dhfr</i> triple mutant H<sub>e</sub> changes over time (50R/108N).

<p>The figure shows variation in H<sub>e</sub> surrounding <i>dhfr</i> for parasites carrying a 51I/108N double mutant during the 1980s (n = 10) and the 1990s (n = 8). The two flat, dashed lines represent two different estimates of neutral H<sub>e</sub> in Brazil.</p>