Figure_5.tif (529.04 kB)

Zaprinast reduces eEPSC amplitude at CA3→CA1 synapse in a PDE5-and cGMP-indipendent manner.

figure

posted on 2013-11-29, 03:07 authored by Rolando Berlinguer-Palmini, Alessio Masi, Roberto Narducci, Leonardo Cavone, Dario Maratea, Andrea Cozzi, Maria Sili, Flavio Moroni, Guido Mannaioni

A and C) Time course of the zaprinast-induced decrease in eEPSC amplitude alone (A) and in the presence of Rp-8-Br (a cGMP-dependent protein kinase-PKG- inhibitor). EPSCs are normalized to pre-application amplitude values. Sample traces (at top) were obtained before (left) and during (right) zaprinast application and represent averages of 5 traces. Rp-8-Br was pre incubated for at least 10 min before zaprinast application. B) Time course of the effect of sildenafil (a PDE5 inhibitor) showing no effect on EPSC amplitude. Sample traces (at top) were obtained before (left) and during (right) sildenafil application and represent averages of 5 traces. D) Bar graph of maximal effect of zaprinast application, with or without Rp-8-Br, and sildenafil.