X-linked inheritance of bovine streaked hairlessness.

(A) Family tree of four affected females (black symbols). The males are indicated by squares, the females by circles. Deduced X chromosome haplotypes are shown colored below the individuals. Y chromosomes are shown in grey. Note the red haplotype spanning the entire chromosome X is shared by all the affected animals. In one of the two non-affected male offspring of case 1, a recombinant haplotype was detected which helped to exclude the proximal part of the X chromosome. The position of both genes (TSR2 and ERCC6L) containing disease-associated variants are shown. (B) Genome regions showing positive LOD scores in linkage analysis are shown in orange.