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Vaccines based on full-length protein immunogens elicit subdominant responses to beneficial regions and / or conserved elements within the HIV proteome.
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posted on 2015-02-27, 03:57 authored by Gemma Hancock, Hongbing Yang, Elisabeth Yorke, Emma Wainwright, Victoria Bourne, Alyse Frisbee, Tamika L. Payne, Mark Berrong, Guido Ferrari, Denis Chopera, Tomas Hanke, Beatriz Mothe, Christian Brander, M. Juliana McElrath, Andrew McMichael, Nilu Goonetilleke, Georgia D. Tomaras, Nicole Frahm, Lucy DorrellA. Post-vaccination, pre-infection CD8+ T cell responses to overlapping peptides spanning the MRK Ad5 Gag/Pol/Nef immunogen determined by IFN-γ Elispot assay in 13 HVTN 502 participants (dark blue bars) (4 weeks post-second vaccination). Responses to beneficial regions and Gag conserved elements within the immunogen are indicated by magenta and turquoise bars respectively. B. Pre- and post-vaccination responses to beneficial and non-beneficial regions within Gag determined by IFN-γ Elispot assay in 9 HIV-positive subjects after therapeutic vaccination with MVA.HIVA.
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HIV Vaccine trials Networkdata support HIV immunogen designconservation algorithmsViral inhibitionimmunodominance hierarchiesT cell responseregionVirus Controlvaccines encodingHIV controlHLA classHIV proteinsviremic controllersHIV immunogenimmunodominant decoy epitopeshvtnHIV replicationvcVaccine development
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