Table_1.xls (5.5 kB)
Tumor incidence of parental PC9 cells and normoxic and hypoxic GRPs transplanted into NOG mice.
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posted on 2014-01-28, 03:49 authored by Akiko Murakami, Fumiyuki Takahashi, Fariz Nurwidya, Isao Kobayashi, Kunihiko Minakata, Muneaki Hashimoto, Takeshi Nara, Motoyasu Kato, Ken Tajima, Naoko Shimada, Shin-ichiro Iwakami, Mariko Moriyama, Hiroyuki Moriyama, Fumiaki Koizumi, Kazuhisa TakahashiGRPs; Gefitinib resistant persisters.
NOG mice; NOD/Shi-scid/IL-2Rcnull (NOG) mice.
#Tumor incidence was increased significantly in hypoxic GRPs group as compared with parental cell group with 1×101 cells/injection, p<0.05.
To evaluate the in vivo tumorigenic potential, 1×10 cells or 1×102 cells of parental PC9 cells or normoxic and hypoxic PC9 GRPs were mixed with Matrigel and injected into both flanks of NOG mice. Tumor formation was evaluated 33 days after injection.
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Molecular cell biologyCellular typesstem cellsStem cell nicheSignal transductionSignaling pathwaysInsulin-dependent signal transductionCell growthgene expressiononcologyCancer treatmentChemotherapy and drug treatmentCancers and neoplasmsLung and intrathoracic tumorsNon-small cell lung cancerincidencepc9cellsnormoxichypoxicgrpstransplantednog
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