Transverse sections of statistical parametric maps show the progression of Mn<sup>2+</sup> accumulation over time.

<p>Representative transverse sections through the statistical parametric maps show the progression of Mn<sup>2+</sup> accumulation over time. Gray background is pre-injection MDT, while the green (1 hr > pre-injection), red (4 hr >1 hr), yellow (8 hr >4 hr) and blue (26 hr >8 hr) overlays indicate areas with increased intensity (P<0.00025) compared to the preceding time point. Videos in Supplemental Data show the complete image data sets for each genotype (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011506#pone.0011506.s004" target="_blank">Video S3</a>). Slice locations are indicated relative to the brain. Scale bars  = 1 mm.</p>