Transition between the Caudate Migratory Stream (CMS) and Rostral Migratory Stream (RMS) and the RMS and olfactory bulbs (OB).

A–C. Transition between the CMS and RMS. The RMS in the adult mouse brain departs from the most anterior end of the caudoputamen (CP). A. The distribution of EdU-labeled nuclei in the lateral walls of the lateral ventricles (shown as yellow dots) has no overlap with the distribution of EdU-labeled nuclei in the RMS (shown as lilac dots). B. The distribution of EdU-labeled nuclei in the dorsal and lateral caudate walls (shown as blue dots) overlaps with the distribution of EdU-labeled nuclei in the RMS (shown as lilac dots). C. Transverse section of the mouse brain stained for EdU. EdU-labeled nuclei in the caudate walls are shown with blue arrows, in the RMS with lilac arrows, in the lateral walls of the lateral ventricles with yellow arrows and the point of transition between the caudate walls and the RMS with red arrows. D, E. Transition between the RMS and OB. The stream of proliferating cells in the RMS does not extend into the olfactory bulbs. EdU-labeled nuclei in the RMS are shown as lilac dots and in the OB as olive dots. EdU-labeled nuclei in the RMS and OB are shown as they are located in the mouse brain (D) or virtually separated by 4 mm to show that the stream of proliferating cells in the RMS does not extend into the OB (E). 120 days-old mouse one hour post EdU injection.