Figure_8.tif (242 kB)
Total MAPT and MAPT3R transcripts are up-regulated under cholesterol fed conditions.
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posted on 2013-06-21, 04:11 authored by Mathew J. Sharman, Seyyed H. Moussavi Nik, Mengqi M. Chen, Daniel Ong, Linda Wijaya, Simon M. Laws, Kevin Taddei, Morgan Newman, Michael Lardelli, Ralph N. Martins, Giuseppe VerdileQuantitative PCR analysis shows that, in comparison to animals fed a control diet, guinea pigs fed a cholesterol rich diet showed a significant increase in (A) total MAPT (p = 0.031, t = 3.560, d.f. = 14) and (B) MAPT3R (p<0.0001, t = 6.468, d.f. = 14) transcripts but (C) no change was observed in MAPT4R transcripts (p = 0.1320, t = 1.60, d.f. = 14, ns). An increased 3R/4R ratio was observed (p = 0.0007, t = 4.326, d.f. = 14). Data is represented as fold change from control fed animals. Transcript levels were normalised against RPS16. Data represents ± SEM.
