The regional distribution of [¹²⁵I]WYE-230949 uptake in rat brain sections.

Ex vivo autoradiograms show the distribution and regional levels of radioactivity in the tissue at 30 or 120 min after administration of [¹²⁵I]WYE-230949. In vitro autoradiograms show total and non-specific binding following incubation with 5 nM [¹²⁵I]WYE-230949 or 5 nM [¹²⁵I]WYE-230949+5 µM iodophenpropit respectively. Note the relatively low level of binding in the cerebellum, the reference region used to calculate region of interest specific binding ratios presented in Table 1 with higher binding in the substantia nigra, nucleus accumbens, choroid plexus and pineal gland.