Figure_3.tif (2.4 MB)
The effect of SIP and fludarabine on leptin-induced Stat1 and Stat3 activation.
figure
posted on 2013-02-20, 01:53 authored by Eduardo Martinez-Abundis, Venkatesh Rajapurohitam, James V. Haist, Xiaohong T. Gan, Morris KarmazynPanels A and B show time-dependent leptin-induced increases in Stat1 phosphorylation in the absence or presence of the Stat inhibitory peptide (SIP), respectively. Panel C shows complete inhibition of leptin-induced Stat1 phosphorylation by fludarabine although the increased Stat3 phosphorylation was unaffected (panel D). As shown in the inset (panel E) fludarabine had no effect on leptin-induced mPTP opening. Values indicate mean + SEM, N = 5. *P<0.05 from control (Ctl).
