Table_4.xls (9.5 kB)
The distributions of the primary outcome measure and other characteristics of plasma cortisol and plasma ACTH in the combined DEX-CRH test in 73 healthy first-degree relatives of patients with a history of major depressive disorder, in the escitalopram 10 mg group (N = 38) and the placebo group (N = 35).
dataset
posted on 2013-02-20, 17:16 authored by Ulla Knorr, Maj Vinberg, Allan Hansen, Marianne Klose, Ulla Feldt-Rasmussen, Linda Hilsted, Jørgen Hasselstrøm, Ulrik Gether, Per Winkel, Christian Gluud, Jørn Wetterslev, Lars Vedel KessingΔ was the difference between the measurement of plasma cortisol and ACTH after and before four weeks of intervention with escitalopram 10 mg or placebo for: AUCtotal = Area under the curve after administration of CRH corrected for baseline equivalent, BASAL = mean of five measurements at the baseline after pre-treatment with dexametasone 1.5 mg and before the administration of CRH, PEAK = the highest measurement following CRH administration,
a)Δplasma cortisol AUCtotal was the primary outcome measure.
b)p of Mann-Whitney test comparing the two distributions which did not follow normal distributions (Shapiro Wilkes test).
*95% C.I. are reported since the distributions followed normal distributions.