Figure_1.tif (2.22 MB)
The LAMTOR complex as a convergence point of MAPK and mTORC1 pathways (Schematic overview).
figure
posted on 2013-01-16, 01:51 authored by Mariana E. De Araujo, Gertraud Erhart, Katharina Buck, Elisabeth Müller-Holzner, Michael Hubalek, Heidelinde Fiegl, Daniele Campa, Federico Canzian, Ursula Eilber, Jenny Chang-Claude, Stefan Coassin, Margot Haun, Lyudmyla Kedenko, Bernhard Paulweber, Roland Reitsamer, Irmgard Himmel, Dieter Flesch-Janys, Claudia Lamina, Florian Kronenberg, Lukas A. Huber, Anita Kloss-BrandstätterInternalized activated receptors keep their ability to signal while they traffic through the endocitic compartment. The arrival at late endosomes/multivesicular bodies of the activated receptor and the detection of aminoacids in the lumen of the organelle, trigger a cascade of phosphorylation events leading to the local activation of both mTORC1 and ERK1/2. The p18/Mp1/p14 complex, also known as the LAMTOR complex was shown to function as a convergence point for both pathways. Both signaling cascades were simplified for didactic reasons.
