The LAMTOR complex as a convergence point of MAPK and mTORC1 pathways (Schematic overview).
2013-01-16T01:51:35Z (GMT) by
<p>Internalized activated receptors keep their ability to signal while they traffic through the endocitic compartment. The arrival at late endosomes/multivesicular bodies of the activated receptor and the detection of aminoacids in the lumen of the organelle, trigger a cascade of phosphorylation events leading to the local activation of both mTORC1 and ERK1/2. The p18/Mp1/p14 complex, also known as the LAMTOR complex was shown to function as a convergence point for both pathways. Both signaling cascades were simplified for didactic reasons.</p>