Fig_4.tif (1.37 MB)
Temporal changes in serum AST and ALT activities in C57BL/6 and BALB/c mice at different p.i. time points and correlation analysis between the serum levels of miRNAs, liver enzymes and the severity of hepatopathology.
figure
posted on 2015-07-31, 03:36 authored by Pengfei Cai, Geoffrey N. Gobert, Hong You, Mary Duke, Donald P. McManusSerum AST and ALT activities were more dramatically up-regulated in BALB/c mice than in C57BL/6 mice during S. japonicum infection (A). Statistical significance between infected and naive mice was determined using 1-Way ANOVA. (* = P<0.05, ** = P<0.01, *** = P<0.001, **** = P<0.0001, ns = no significant difference). Correlations between the serum levels of miRNAs and AST level (B); ALT level (C), the severity of liver necrosis (D) and hepatic fibrosis (E) in both mouse strains were performed using Spearman’s Rho correlation.