Temporal appearance of MxA resistance enhancing amino acids in NP of human and swine influenza A viruses.

Bold letters indicate amino acids in NP shown to increase significantly MxA resistance, whereas amino acids highlighted in grey are minor contributors. Adaptive mutations that newly emerged with the appearance of the 2009 pandemic pH1N1 strain are depicted in red. 53D got partially lost after re-introduction of pH1N1 into the swine host.