T cell motion in absence and presence of chemotaxis.

<p>(<b>A</b>) 2D snapshot of a simulation with the DC-contact desensitization mechanism showing sensitive T cells (blue), insensitive T cells (yellow), DCs (red), reticular network (green), and the ‘LN capsule’ at the top (cyan). T cells enter in the region indicated by the red square, and leave at the boundary at the bottom. (<b>B</b>) Overlay of T cell tracks from a 10 min period in x and y coordinates after aligning their starting positions to the origin. (<b>C</b>) Mean square displacement plots (averages s.e.m.) for the different migration mechanisms. Cellular motility parameters were estimated after combining the data from 10 simulations (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002763#s4" target="_blank">Methods</a>). The estimated motility coefficient, , and persistence time, , ( s.e.m.) are: and min for random migration; , min for the no-desensitization mechanism; and , min for the DC-contact mechanism.</p>