T_FH2 cell frequency is significantly increased in active SLE patients.

Correlations between the SLEDAI score and the percentage of each T_FH cell subset from SLE patients (n = 19) are shown (A). Dot plots of CXCR3 and CCR6 expression on gated CD3⁺CD4⁺CD45RA^-CXCR5⁺ T cells from an healthy individual, an inactive SLE patient and an active patient are shown as examples (B). T_FH2 and T_FH1 cell subset frequencies were analyzed according to the presence or the absence of anti-dsDNA Abs (C). Each data point represents an individual subject; horizontal lines show the mean ± sem. *p < 0.05, **p < 0.01, ***p < 0.001 (unpaired Student’s t test and Spearman’s rank correlation test). ns: not significant.