Systolic blood pressure (SBP) after 5/6 nephrectomy (Nx) during the light period in mice fed a high-salt diet and a normal-salt diet.

Fig 1A shows changes in SBP of high-salt diet (8% NaCl) groups after 6 weeks, whereas Fig 1B shows SBP changes in normal-salt diet (0.3% NaCl) groups. After 8 weeks, mice were administered drugs or vehicle. In high-salt groups, azilsartan significantly reduced SBP compared with candesartan and vehicle, and candesartan significantly reduced SBP compared with vehicle. In normal-salt diet groups, there were no significant differences in SBP. Data represent mean ± standard deviation. n = 3–6 for each group. *P < 0.05 azilsartan vs. vehicle, azilsartan vs. candesartan, and candesartan vs. vehicle. #P < 0.05 SBP (week 7) vs. SBP (week 6) for each group.